Astronauts Bob Behnken and Doug Hurley are expected to return to Earth on Sunday, and they could splash down off the coast of Pensacola according to NASA.
NASA and SpaceX identified seven potential sites all around the Florida peninsula.
The target site and a back-up will be selected before the Crew Dragon detaches from the International Space Station.
Key factors that NASA will consider are:
• Where the space station is in orbit when they undock.
• The weather on the day of touchdown.
The track of storm Isaias will have some impacts around several of the potential sites.
NASA could also decide to postpone the return flight for a few days until the storm passes.
Whenever it happens, this will be the first splashdown for NASA astronauts since 1975.